Comparative study on complement fixation technics in rickettsial diseases

Complement fixation in Q fever. I. Comparative evaluation of several technics.

Q fever, an acute febrile disease which had been prevalent among workers at slaughter-houses and live-stock dealers in Australia, was first described by Derric1) in 1937, and it was found by Burnet2) that the disease was caused by a sort of rickettsia, which was named Rickettsia burnetii by Derrick3) (afterwards Coxiella burnetii by Bengtson). In United States of America, Davis4) isolated from ...

Recent experience with the complement fixation test in the laboratory diagnosis of rickettsial diseases in the United States.

Sera from patients suspected of having rickettsial infections were tested in the complement fixation test with antigens prepared from the rickettsiae of Rocky Mountain spotted fever (SF), rickettsial pox (RP), murine typhus, epidemic typhus, and from Rickettsia canada (RC). Eight units of antigen were used in all cases and two units in man. Only those patients with antibody titers of 1:16 or hi...

IAP Guidelines on Rickettsial Diseases in Children.

OBJECTIVE To formulate practice guidelines on rickettsial diseases in children for pediatricians across India. JUSTIFICATION Rickettsial diseases are increasingly being reported from various parts of India. Due to low index of suspicion, nonspecific clinical features in early course of disease, and absence of easily available, sensitive and specific diagnostic tests, these infections are diff...

Studies on Complement Fixation

It is shown by complement fixation studies with protein antigens and specific immune rabbit sera that the rate of fixation of complement is determined by the concentration of antibodies in the immune sera, that the greater part of fixation of complement takes place during the 1st hour, and that fixation is practically completed at the end of 4 hours at ice box temperature. It is further shown t...

Treatment in the Rickettsial Diseases